In this innovative text, Bruice balances coverage of traditional topics with bioorganic chemistry to show how organic chemistry is related to biological systems and to our daily lives. Functional groups are organized around mechanistic similarities, emphasizing what functional groups do rather than how they are made. Tying together the reactivity of a functional group and the synthesis of compounds resulting from its reactivity prevents students from needing to memorize lists of unrelated reactions. The Sixth Edition has been revised and streamlined throughout to enhance clarity and accessibility, and adds a wealth of new problems and problem-solving strategies.