THE FIRST MAJOR WORK IN NEARLY A DECADE BY ONE OF THE WORLD’S GREAT THINKERS—A MARVELOUSLY CONCISE BOOK WITH NEW ANSWERS TO THE ULTIMATE QUESTIONS OF LIFE When and how did the universe begin? Why are we here? Why is there something rather than nothing? What is the nature of reality? Why are the laws of nature so finely tuned as to allow for the existence of beings like ourselves? And, finally, is the apparent “grand design” of our universe evidence of a benevolent creator who set things in motion—or does science offer another explanation? The most fundamental questions about the origins of the universe and of life itself, once the province of philosophy, now occupy the territory where scientists, philosophers, and theologians meet—if only to disagree. In their new book, Stephen Hawking and Leonard Mlodinow present the most recent scientific thinking about the mysteries of the universe, in nontechnical language marked by both brilliance and simplicity. In The Grand Design they explain that according to quantum theory, the cosmos does not have just a single existence or history, but rather that every possible history of the universe exists simultaneously. When applied to the universe as a whole, this idea calls into question the very notion of cause and effect. But the “top-down” approach to cosmology that Hawking and Mlodinow describe would say that the fact that the past takes no definite form means that we create history by observing it, rather than that history creates us. The authors further explain that we ourselves are the product of quantum fluctuations in the very early universe, and show how quantum theory predicts the “multiverse”—the idea that ours is just one of many universes that appeared spontaneously out of nothing, each with different laws of nature.Along the way Hawking and Mlodinow question the conventional concept of reality, posing a “model-dependent” theory of reality as the best we can hope to find. And they conclude with a riveting assessment of M-theory, an explanation of the laws governing us and our universe that is currently the only viable candidate for a complete “theory of everything.” If confirmed, they write, it will be the unified theory that Einstein was looking for, and the ultimate triumph of human reason.A succinct, startling, and lavishly illustrated guide to discoveries that are altering our understanding and threatening some of our most cherished belief systems, The Grand Design is a book that will inform—and provoke—like no other.

Style manual for writers, editors, students, educators, and professionals across all fields. Provides clear guidance on grammar, the mechanics of writing, and APA style. Includes examples, new guidelines and advice, and more. Previous edition: c1994. Softcover, wire-spiral edition is also available. Hardcover edition due later.

Oliver Twist is a classic tale of a boy of unknown parentage born in a workhouse and brought up under the cruel conditions to which pauper children were exposed in the Victorian England. With this novel, Dickens did not merely write a topical satire on the workhouse system and the role of the 1834 New Poor Law in fostering criminality. He created a moral fable about the survival of good, a romance, and a gripping story in which he exploited suspense and violence more effectively than any of his contemporaries. The new Oxford World's Classics edition of Oliver Twist is based on the authoritative Clarendon edition, which uses Dickens's revised text of 1846. It includes his preface of 1841 in which he defended himself against hostile criticism, and includes all twenty-four original illustrations by George Cruikshank. Stephen Gill's groundbreaking introduction gives a fascinating new account of the novel. He also provides appendices on Dickens and Cruikshank, on Dickens's Preface and the Newgate Novel Controversy, on Oliver Twist and the New Poor Law and on thieves' slang.

The best-selling author of Stiff and Bonk explores the irresistibly strange universe of space travel and life without gravity. Space is a world devoid of the things we need to live and thrive: air, gravity, hot showers, fresh produce, privacy, beer. Space exploration is in some ways an exploration of what it means to be human. How much can a person give up? How much weirdness can they take? What happens to you when you can’t walk for a year? have sex? smell flowers? What happens if you vomit in your helmet during a space walk? Is it possible for the human body to survive a bailout at 17,000 miles per hour? To answer these questions, space agencies set up all manner of quizzical and startlingly bizarre space simulations. As Mary Roach discovers, it’s possible to preview space without ever leaving Earth. From the space shuttle training toilet to a crash test of NASA’s new space capsule (cadaver filling in for astronaut), Roach takes us on a surreally entertaining trip into the science of life in space and space on Earth.

“A compelling, witty, and reader-friendly explanation of how our genes, fashioned for living in the Stone Age, are not so well-suited to life in the Modern Age.” —Sean B. Carroll, author of The Making of the Fittest and Remarkable Creatures   “It’s taken thirty years, but we finally have in Greg Gibson’s It Takes a Genome what is truly a biologist’s response to the single-gene focus of Richard Dawkin’s early classic The Selfish Gene. And what a response it is! In Gibson’s world, we see a genome as an integrated whole, making sense only when the constituent parts, the genes, are considered in their full genomic and environmental context. It is an engaging, fascinating, accessible, and ultimately deeply satisfying perspective that will enrich the way we all think about ourselves and how we got to be the way we are.” —David B. Goldstein, Professor of Molecular Genetics, Duke University   “Gibson has captured the delicate balance between the excitement of the genomic revolution and the frustration that so much is yet to be learned about the genomics of disease. This book is an ideal guide through the complexities of recent environmental change and how this non-genetic process has interacted with human genomic variation to produce today’s landscape of important chronic diseases.” —Marc Feldman, Professor of Biology, Stanford University   “Gibson deftly synthesizes the new science linking genome variation and human health, debunking entrenched views about the causes and evolution of disease and arguing convincingly for a more comprehensive view. An important book and a great read.” —David P. Mindell, Dean of Science, California Academy of Sciences   “Geneticist Gibson is a natural teacher. He brings a welcome balance to his descriptions of the roles of genes, the environment, and chance in the major human diseases.” —Bruce Weir, Chair and Professor of Biostatistics, University of Washington     Human beings have astonishing genetic vulnerabilities. More than half of us will die from complex diseases that trace directly to those vulnerabilities, and the modern world we’ve created places us at unprecedented risk from them. In It Takes a Genome, Greg Gibson posits a revolutionary new hypothesis: Our genome is out of equilibrium, both with itself and its environment. Simply put, our genes aren’t coping well with modern culture. Our bodies were never designed to subsist on fat and sugary foods; our immune systems weren’t designed for today’s clean, bland environments; our minds weren’t designed to process hard-edged, artificial electronic inputs from dawn ‘til midnight. And that’s why so many of us suffer from chronic diseases that barely touched our ancestors. Gibson begins by revealing the stunningly complex ways in which multiple genes cooperate and interact to shape our bodies and influence our behaviors. Then, drawing on the very latest science, he explains the genetic “mismatches” that increasingly lead to cancer, diabetes, inflammatory and infectious diseases, AIDS, depression, and senility. He concludes with a look at the probable genetic variations in human psychology, sharing the evidence that traits like introversion and agreeableness are grounded in equally complex genetic interactions. It Takes A Genome demolishes yesterday’s stale debates over “nature vs. nurture,” introducing a new view that is far more intriguing, and far closer to the truth.       See how broken genes cause cancerMeet the body’s “genetic repairmen”–and understand what happens when they fail The growing price of the modern lifestyleWhy one-third of all Westerners have obesity, Type 2 diabetes, or other signs of “metabolic syndrome” The Alzheimer’s generationWhy some of us are predisposed to dementia What’s really normal: the deepest lessons of the human genomeThe remarkable diversity of physical and emotional “normality”

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?           Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

It's Time to Rediscover the Wonderful Books We All Cherish."The Mississippi is well worth reading about. It is not a commonplace river but on the contrary is in all ways remarkable."-- Mark Twain0riginally published in 1883, Life on the Mississippi is Mark Twain's memoir of his youthful years as a cub pilot on a steamboat paddling up and down the Mississippi River. Twain used his childhood experiences growing up along the Mississippi in a number of works, including The Adventures of Tom Sawyer and The Adventures of Huckleberry Finn, but nowhere is the river and the pilot's life more thoroughly described than in this work. Told with insight, humor, and candor, Life on the Mississippi is an American classic.