Winner of the National Book Critics Circle Award for NonfictionWhen three-month-old Lia Lee Arrived at the county hospital emergency room in Merced, California, a chain of events was set in motion from which neither she nor her parents nor her doctors would ever recover. Lia's parents, Foua and Nao Kao, were part of a large Hmong community in Merced, refugees from the CIA-run "Quiet War" in Laos. The Hmong, traditionally a close-knit and fiercely people, have been less amenable to assimilation than most immigrants, adhering steadfastly to the rituals and beliefs of their ancestors. Lia's pediatricians, Neil Ernst and his wife, Peggy Philip, cleaved just as strongly to another tradition: that of Western medicine. When Lia Lee Entered the American medical system, diagnosed as an epileptic, her story became a tragic case history of cultural miscommunication.Parents and doctors both wanted the best for Lia, but their ideas about the causes of her illness and its treatment could hardly have been more different. The Hmong see illness aand healing as spiritual matters linked to virtually everything in the universe, while medical community marks a division between body and soul, and concerns itself almost exclusively with the former. Lia's doctors ascribed her seizures to the misfiring of her cerebral neurons; her parents called her illness, qaug dab peg--the spirit catches you and you fall down--and ascribed it to the wandering of her soul. The doctors prescribed anticonvulsants; her parents preferred animal sacrifices.

In his latest bestseller, Atul Gawande shows what the simple idea of the checklist reveals about the complexity of our lives and how we can deal with it.The modern world has given us stupendous know-how. Yet avoidable failures continue to plague us in health care, government, the law, the financial industry—in almost every realm of organized activity. And the reason is simple: the volume and complexity of knowledge today has exceeded our ability as individuals to properly deliver it to people—consistently, correctly, safely. We train longer, specialize more, use ever-advancing technologies, and still we fail. Atul Gawande makes a compelling argument that we can do better, using the simplest of methods: the checklist. In riveting stories, he reveals what checklists can do, what they can’t, and how they could bring about striking improvements in a variety of fields, from medicine and disaster recovery to professions and businesses of all kinds. And the insights are making a difference. Already, a simple surgical checklist from the World Health Organization designed by following the ideas described here has been adopted in more than twenty countries as a standard for care and has been heralded as “the biggest clinical invention in thirty years” (The Independent).

Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy, with carefully controlled double-blind trials, hundreds of patients, and clear indicators of success. Well, Eric Topol isn’t most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar. It turns out plenty of new medicines—although tested with what seem like large trials—actually end up revealing most of their problems only once they get out in the real world, with millions of people with all kinds of conditions mixing them with everything in the pharmacopeia. The unexpected interactions of drugs, patients, and diseases can be devastating. And the clear indicators of success often turn out to be minimal, often as small as one fewer person dying out of a hundred (or even a thousand), and often at exorbitant cost. How can we avoid these dangerous interactions and side-effects? How can we predict which person out of a hundred will be helped by a new drug, and which fatally harmed? And how can we avoid having to need costly drugs in the first place? It sure isn’t by doing another 400-person trial. As Topol argues in The Creative Destruction of Medicine, it’s by bringing the era of big data to the clinic, laboratory, and hospital, with wearable sensors, smartphone apps, and whole-genome scans providing the raw materials for a revolution. Combining all the data those tools can provide will give us a complete and continuously updated picture of every patient, changing everything from the treatment of disease, to the prolonging of health, to the development of new treatments. As revolutionary as the past twenty years in personal technology and medicine have been—remember phones the sizes of bricks that only made calls, or when the most advanced “genotyping” we could do involved discerning blood types and Rh-factors?—Topol makes it clear that we haven’t seen a thing yet. With an optimism matched only by a realism gained through 25 years in a tough job, Topol proves the ideal guide to the medicine of the future—medicine he himself is deeply involved in creating. AMONG THE INNOVATIONS COVERED: At home brain-monitors helping us improve our sleep.Sensors to track all vital signs, catching everything from high blood pressure to low blood sugar to heart arrhythmia without invasive measurements to inconvenient and nerve-wracking—or even dangerous—hospital stays (which kill some 100,000 every year, due to infections caught there, or patients getting someone else’s medicine). Improved imaging techniques and the latest in printing technology are beginning to enable us to print new organs, rather than looking for donors. Genetics can reveal who might be helped by a drug, unaffected by it, or even killed by it, helping avoid problems as were seen with Vioxx.

“A compelling, witty, and reader-friendly explanation of how our genes, fashioned for living in the Stone Age, are not so well-suited to life in the Modern Age.” —Sean B. Carroll, author of The Making of the Fittest and Remarkable Creatures   “It’s taken thirty years, but we finally have in Greg Gibson’s It Takes a Genome what is truly a biologist’s response to the single-gene focus of Richard Dawkin’s early classic The Selfish Gene. And what a response it is! In Gibson’s world, we see a genome as an integrated whole, making sense only when the constituent parts, the genes, are considered in their full genomic and environmental context. It is an engaging, fascinating, accessible, and ultimately deeply satisfying perspective that will enrich the way we all think about ourselves and how we got to be the way we are.” —David B. Goldstein, Professor of Molecular Genetics, Duke University   “Gibson has captured the delicate balance between the excitement of the genomic revolution and the frustration that so much is yet to be learned about the genomics of disease. This book is an ideal guide through the complexities of recent environmental change and how this non-genetic process has interacted with human genomic variation to produce today’s landscape of important chronic diseases.” —Marc Feldman, Professor of Biology, Stanford University   “Gibson deftly synthesizes the new science linking genome variation and human health, debunking entrenched views about the causes and evolution of disease and arguing convincingly for a more comprehensive view. An important book and a great read.” —David P. Mindell, Dean of Science, California Academy of Sciences   “Geneticist Gibson is a natural teacher. He brings a welcome balance to his descriptions of the roles of genes, the environment, and chance in the major human diseases.” —Bruce Weir, Chair and Professor of Biostatistics, University of Washington     Human beings have astonishing genetic vulnerabilities. More than half of us will die from complex diseases that trace directly to those vulnerabilities, and the modern world we’ve created places us at unprecedented risk from them. In It Takes a Genome, Greg Gibson posits a revolutionary new hypothesis: Our genome is out of equilibrium, both with itself and its environment. Simply put, our genes aren’t coping well with modern culture. Our bodies were never designed to subsist on fat and sugary foods; our immune systems weren’t designed for today’s clean, bland environments; our minds weren’t designed to process hard-edged, artificial electronic inputs from dawn ‘til midnight. And that’s why so many of us suffer from chronic diseases that barely touched our ancestors. Gibson begins by revealing the stunningly complex ways in which multiple genes cooperate and interact to shape our bodies and influence our behaviors. Then, drawing on the very latest science, he explains the genetic “mismatches” that increasingly lead to cancer, diabetes, inflammatory and infectious diseases, AIDS, depression, and senility. He concludes with a look at the probable genetic variations in human psychology, sharing the evidence that traits like introversion and agreeableness are grounded in equally complex genetic interactions. It Takes A Genome demolishes yesterday’s stale debates over “nature vs. nurture,” introducing a new view that is far more intriguing, and far closer to the truth.       See how broken genes cause cancerMeet the body’s “genetic repairmen”–and understand what happens when they fail The growing price of the modern lifestyleWhy one-third of all Westerners have obesity, Type 2 diabetes, or other signs of “metabolic syndrome” The Alzheimer’s generationWhy some of us are predisposed to dementia What’s really normal: the deepest lessons of the human genomeThe remarkable diversity of physical and emotional “normality”

This compelling and inspiring book, now in a deluxe paperback edition, shows how one person can work wonders. In Mountains Beyond Mountains, Pulitzer Prize—winning author Tracy Kidder tells the true story of a gifted man who loves the world and has set out to do all he can to cure it.In medical school, Paul Farmer found his life’s calling: to cure infectious diseases and to bring the lifesaving tools of modern medicine to those who need them most. Kidder’s magnificent account takes us from Harvard to Haiti, Peru, Cuba, and Russia as Farmer changes minds and practices through his dedication to the philosophy that “the only real nation is humanity.” At the heart of this book is the example of a life based on hope and on an understanding of the truth of the Haitian proverb “Beyond mountains there are mountains”–as you solve one problem, another problem presents itself, and so you go on and try to solve that one too.“Mountains Beyond Mountains unfolds with a force of gathering revelation,” says Annie Dillard, and Jonathan Harr notes, “[Paul Farmer] wants to change the world. Certainly this luminous and powerful book will change the way you see it.”

Correctly interpreting and reporting medical procedures and services begins with CPT® 2012 Professional Edition. Straight from the American Medical Association (AMA), this is the only CPT codebook with the official CPT coding rules and guidelines developed by the CPT Editorial Panel. Covers hundreds of code, guideline and text changes.

How We Do Harm exposes the underbelly of healthcare today—the overtreatment of the rich, the under treatment of the poor, the financial conflicts of interest that determine the care that physicians’ provide, insurance companies that don’t demand the best (or even the least expensive) care, and pharmaceutical companies concerned with selling drugs, regardless of whether they improve health or do harm. Dr. Otis Brawley is the chief medical and scientific officer of The American Cancer Society, an oncologist with a dazzling clinical, research, and policy career. How We Do Harm pulls back the curtain on how medicine is really practiced in America. Brawley tells of doctors who select treatment based on payment they will receive, rather than on demonstrated scientific results; hospitals and pharmaceutical companies that seek out patients to treat even if they are not actually ill (but as long as their insurance will pay); a public primed to swallow the latest pill, no matter the cost; and rising healthcare costs for unnecessary—and often unproven—treatments that we all pay for. Brawley calls for rational healthcare, healthcare drawn from results-based, scientifically justifiable treatments, and not just the peddling of hot new drugs.Brawley’s personal history – from a childhood in the gang-ridden streets of black Detroit, to the green hallways of Grady Memorial Hospital, the largest public hospital in the U.S., to the boardrooms of The American Cancer Society—results in a passionate view of medicine and the politics of illness in America - and a deep understanding of healthcare today. How We Do Harm is his well-reasoned manifesto for change.

Thomas S. Kuhn's classic book is now available with a new index. "A landmark in intellectual history which has attracted attention far beyond its own immediate field. . . . It is written with a combination of depth and clarity that make it an almost unbroken series of aphorisms. . . . Kuhn does not permit truth to be a criterion of scientific theories, he would presumably not claim his own theory to be true. But if causing a revolution is the hallmark of a superior paradigm, [this book] has been a resounding success." —Nicholas Wade, Science "Perhaps the best explanation of [the] process of discovery." —William Erwin Thompson, New York Times Book Review "Occasionally there emerges a book which has an influence far beyond its originally intended audience. . . . Thomas Kuhn's The Structure of Scientific Revolutions . . . has clearly emerged as just such a work." —Ron Johnston, Times Higher Education Supplement "Among the most influential academic books in this century." —Choice One of "The Hundred Most Influential Books Since the Second World War," Times Literary Supplement 

You won’t have to worry about going broke if you get sick. We will start to bring the costs of health care under control. And we will do all this while reducing the federal deficit. That is the promise of the Affordable Care Act. But from the moment President Obama signed the bill into law in 2010, a steady and mounting avalanche of misinformation about the ACA has left a growing majority of Americans confused about what it is, why it’s necessary, and how it works. If you’re one of them, buy this book. From how to tame the twin threats of rising costs and the increasing number of uninsured to why an insurance mandate is good for your health, Health Care Reform dispels false fears by arming you with facts.